EDUCATION/TRAININGState University of N.Y., Stony Brook B.A. 1974 Chemistry State University of N.Y., Stony Brook Ph.D. 1979 Biochemistry
RESEARCH AND PROFESSIONAL EXPERIENCE
Professional Experience:1980-1982 Postdoctoral Fellow, Dana-Farber Cancer Inst. & Harvard University Medical School 1982-1984 Instructor, Dana-Farber Cancer Institute and Harvard University Medical School 1984-1989 Assistant Professor, Department of Biochemistry, Boston University Medical School 1989-1991 Associate Professor, Department of Biochemistry, Boston University Medical School 1991-present Senior Scientist, Life Sciences Division, Berkeley National Laboratory 1992-present Group Leader, Aging and Cancer, Berkeley National Laboratory 1994-1999 Head, Department of Cell and Molecular Biology, Berkeley National Laboratory
Selected Awards and Professional Service:1979-1982 Postdoctoral Fellowships, American Cancer Society and National Institutes of Health 1985 Evangeline Athanas Cancer Research Scholar Award, American Cancer Society 1988 Established Investigator of the American Heart Association 1988-1992 Member, Biological & Clinical Aging Review Committee, National Institute on Aging 1991-present Member, Scientific Advisory Committee, Tobacco Related Disease Research Program 1993-present Member, Scientific Advisory Board, Alliance for Aging Research 1994-1998 Member, Board of Scientific Counselors, National Institute on Aging 1995 MERIT Award, National Institute on Aging 1997 Allied Signal Award for Research on Aging 1999 Senior Scholar Award, Ellison Medical Research Foundation 1999-2002 Member, National Advisory Council on Aging, National Institutes of Health 1999 Glenn Foundation Award, Gerontological Society of America Current Editorial Boards: Experimental Cell Research, Journal of Cellular Biochemistry, Journal of Cellular Physiology, Molecular Biology Reports.
Representative publications since 1994:Hara E , Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K. (1994) Id-related genes encoding HLH proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269: 2139-2145. Dimri GP, Campisi J. (1994) Altered profile of transcription factor binding activities during cellular senescence. Exp. Cell Res. 212:132-140. Hara E, Campisi J. (1994) cDNA synthesis and asymmetric PCR on Oligotex for subtractive cDNA cloning. J. NIH Res. 6: 77. Dimri GP, Hara E, Campisi. (1994) Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269:16180-16186. Dimri GP, Campisi J. (1994) Molecular and cell biology of replicative senescence. Cold Spring Harbor Symp. on Quantitative Biology 59: 67-73. Campisi J, Dimri GP, Hara E. (1994) Control of replicative senescence. In: Handbook of the Biology of Aging. Schneider E, Rowe J, eds. Academic Press, New York, pp. 121-149. Oshima J, Campisi J, Tannock CA, Martin GM. (1995) Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell. Physiol. 162: 277-283. Desprez P, Hara E, Bissell MJ, Campisi J. (1995) Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein, Id-1. Molec. Cell. Bio. 15: 3398-3404. Dimri G, Lee, X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J. (1995) A novel biomarker identifies senescent human cells in culture and aging skin in vivo. Proc. Natl. Acad. Sci. USA 92: 9363-9367. Campisi J. (1996) Replicative senescence: An old lives tale? Cell 84: 497-500. Hara E, Uzman JA, Dimri GP, Nehlin JO, Testori A, Campisi J. (1996) The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev. Genetics 18: 161-172. Campisi J, Dimri GP, Nehlin JO, Testori A, Yoshimoto K. (1996) Coming of age in culture. Exp. Gerontol. 31: 7-12. Dimri GP, Nakanishi M, Desprez PY, Smith JR, Campisi J. (1996) Inhibition of E2F activity by the p21 inhibitor of cyclin-dependent protein kinases in cells expressing and lacking a functional retinoblastoma protein. Molec. Cell. Bio. 16: 2987-2997. Chen H, Campisi J, Padmanabhan R. (1996) SV40 large T antigen transactivates the human cdc2 promoter by inducing a CCAAT-box binding factor. J. Biol. Chem. 271: 13959-13967. Good LF, Dimri GP, Campisi J, Chen KY. (1996) Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J. Cell. Physiol. 168: 580-588. Dimri GP, Testori A, Acosta M, Campisi J. (1996) Replicative senescence, aging and growth regulatory transcription factors. Biol. Signals 5: 154-162. Campisi J. (1997) Aging and cancer: The double-edged sword of replicative senescence. J. Am. Geriatrics Soc. 45: 1-6. Nehlin JO, Hara E, Kuo WL, Collins C, Campisi J. (1997) Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. Biochem. Biophys. Res. Comm. 231: 628-634. Campisi J. (1997) The biology of replicative senescence. Europ. J. Cancer 33: 703-709. Rubelj R, Venable SF, Lednicky J, Butel JS, Bilyeu T, Darlington G, Surmacz E, Campisi J, Pereira-Smith OM. (1997) Loss of T antigen sequences allows SV40-transformed human cells to escape crisis and acquire the senescent phenotype. J. Gerontol. 52: 8229-8234. Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagen JD, Ames BN. (1998) Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G(1) arrest but not cell replication. Biochem. J. 332: 43-50. Desprez PY, Thomasset N, Lin CQ, Sympson CJ, Bissell MJ, Campisi J. (1998) A novel pathway for mammary epithelial cell invasion mediated by the helix-loop-helix protein Id-1. Molec. Cell. Bio. 18: 4577-4588. Campisi J. (1998) The role of cellular senescence in skin aging. J. Investig. Dermatol. 3: 1-5. Huang S, Li B, Mian S, Gray MD, Oshima J, Campisi J. (1998) The premature aging syndrome protein Wrn is a 3' to 5' exonuclease. Nature Genetics 20: 114-116. Dimri GP, Acosta M, Itahana K, Campisi J. (under revision) Regulation of a senescence checkpoint by the E2F1 transcription factor and p14 tumor suppressor. Molec. Cell. Bio. Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ETH, Medrano EE. (under revision) Regulation of Microphtalmia-associated transcription factor MITF by association with the ubiquitin-conjugating enzyme hUBC9. Exp. Cell Res. Kim SH, Kaminker P, Campisi J. (under revision) Tin2, a novel human telomere-associated protein and negative regulator of telomerase. Nature Genetics. Lin CQ, Liang SH, Campisi J, Desprez PY. (submitted) A role for the Id1 protein in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res. Xu W, Haddad M, Angelis K, Shardy DL, Bischof O, Campisi J, Stavenezer E, Medrano EM. (submitted) SKI acts as a co-repressor of Smad2 and Smad3 to regulate the response to TGB-B. Current Biology